Dr. Nash.E.B was one of the pioneers known for his Trio remedies, which means three best remedies for a particular disease condition. It is Dr. Nash who gave much importance to trio remedies. Its because, he gave much importance to therapeutic study Materia medica based on his clinical experience. The other important pioneers are
1. Dr. S. Hahnemann
2. Farrigton.E.A
3. A.G. Clarke
4. N.M. Choudhary

Different conditions for which Trio are known includes:
1. Anti-sporic
2. Asthmatic complications
3. Brain typhus
4. Burning pain
5. Cholera
6. Climatric
7. Condylamata
8. Croup
9. Delirium
10. Drooping eyelids
11. Exhaustion
12. Flatulent
13. Fluent coryza
14. Glandular remedies
15. Restlessness
16. Offensive urine
17. Pain
18. Pneumonia
19. Profuse Expectoration
20. Profuse and purulent (the expectoration)
21. Profuse stringy expectoration
22. Masturbation and excessive venery
23. Sleepiness
24. Spasmodic cough
25. Weakened constitutions
26. Urging and colic

Trios with introducer into Materia Medica are known includes:

1. Antisporic – (Dr.S.Hahnemann)
Sulph; Calc carb & Lyco

2. Asthmatic complications – (Nash.E.B)
Arsenicum; Ipecac and Natrum sulph

3. Brain typhus - (Nash.E.B)
Apis mellifica; Helleborus niger and Zincum metallicum

4. Burning pain - (Nash.E.B)
Ars alb; Sulph & Phos

5. Cholera (Dr.S.Hahnemann)
Camph; Vertrm alba and Cupr

6. Climatric - (Clarke.A.G)
Lachesis; Sepia and Sulphur

7. Condylamata - (Nash.E.B)
Thuj; Staph. and Nitric acid

8. Croup - (Dr.S.Hahnemann)
Aconite; Spongia & Hepar sulph.

9. Delirium - (Nash.E.B)
Bell; Strom & Hyos

10. Drooping eyelids - (Nash.E.B)
Gels; Caust & Sepia.

11. Exhaustion - (Nash.E.B)
Ars alb; Muriatic acid & Carbo veg.

12. Flatulent - (Nash.E.B)
Lyco; Carbo veg & China

13. Fluent coryza - (Nash.E.B)
Ars alb; Allium cepa & Merc

14. Glandular remedies - (Nash.E.B)
Con; Brom & Carb ani

15. Restlessness - (Nash.E.B)
Aconite, Arsenicum and Rhus-toxicodendron.

16. Offensive urine - (Nash.E.B)
Sepia; Nitri acid & Benzoic acid

17. Pain - (Nash.E.B)
Aconite; Cham & Cofee.

18. Pneumonia - (Nash.E.B)
Mercurius, Chelidonium and Kali carb.

19. Profuse Expectoration - (Nash.E.B)
Sanguinaria, Kali hydrod. and Stannum

20. Profuse and purulent (the expectoration) - (Nash.E.B
Hepar sulph., Silicea and Tuberculinum

21. Profuse stringy expectoration - (Nash.E.B)
Kali bich., Hydrastis and Coccus cacti

22. Masturbation and excessive venery – (Farrigton)
Nux vomica, Sulphur and Calcarea,
23. Sleepiness - (Nash.E.B)
Opium; Anti tart & Nux mox

24. Spasmodic cough - (Nash.E.B)
Drosera; Ipecec & cuprum.

25. Weakened constitutions - (Nash.E.B)
Ammonium carb., Cinchona and Carbo vegetab

26. Urging and colic - (Nash.E.B)
Rheum; Colocynth, and jalapa