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 Carcinoma Larynx

  Dr.Sunila BHMS,MD(Hom)

Email : babuabau@gmail.com

 

 

Case

Name of the patient                            Mammed Koya

Address                                               Kamukkayam

                                                            Thiruvannur

                                                            Manari Bypass

Age: 70 years                                      Sex: Male

Admission No: 1317                          Date of Admission: 26/ 03/ 05

Presenting Complaints

1.      Hoarseness of voice (5 months)

Hoarseness with obstructed feeling in throat

No pain in throat

No dysphagia

Hoarseness < evening

2.      Redness of left eye (1 month)

No itching

No pain

No lachrymation

There is sand sensation in left eye.

Dimness of vision for distant objects

History of presenting complaint

Complaint started 5 months back. He took allopathic treatment with radiotherapy.

Past History

No relevant complaints in the past

Family history

No similar complaint among the family members

Personal History

Born and brought up at Mankavu. He has the habit of smoking started at the age of 20. One packet of cigarettes a day and he is still continuing the habit.

 

Regionals

Appetite                      :           Good; Desires pungent food

Thirst                           :           Good

Bowels                        :           Regular

Urine                           :           No complaints

Sweat                          :           N

Sleep                           :           Good

Thermal reaction         :           Not specific

Physical Examination:

Pulse Rate: 68/ minute    Respiratory Rate: 20/ minute

BP: 110/ 70mm of Hg    Temperature : 98.6ºF

General Survey

Moderately built and nourished

Pallor present

No cyanosis, No icterus.

No clubbing, No lymphadenopathy and No pedal oedema.

 O/E: Oral cavity and Oropharynx

Lips                 (N)                   Tongue      (N)

Gums               (N)                   Pillars        (N)     Tonsils    (N)

Internal Larynx Examination

Epiglottis         (N)

There is an ulceroproliferative growth involving the anterior commissures and anterior ⅔ of medial borders and superior surface of (L) vocal cord.

Vocal cords mobile B/L

Neck

No neck node

Carotid palpable (B/L)

Impression     : Carcinoma Larynx T2 N0 M0

Biopsy :

Squamous cell Carcinoma- moderately differentiated

 

Systemic Examination

Examination of Respiratory system

Examination of Upper Respiratory tract

No congestion of nasal mucosa, no deviation of nasal septum& no nasal polyp

Uvula centrally placed & no tonsillar enlargement.

 

Examination of lower Respiratory tract

Inspection

Trachea appears to be centrally placed

Chest wall bilaterally symmetrical

No kyphosis, scoliosis or lordosis; no prominent vessels and visible pulsations.

 

Palpation

No palpable swelling; Trachea centrally placed; Apex beat palpable.

Percussion

Normal lung resonance

Auscultation

No wheeze heard

Examination of Central Nervous system

Examination of higher mental functions

Patient is conscious, intelligent, normal behaviour, past and present memory present, orientation of time, place and person present, no hallucination, delusion, illusion and speech normal.

 

Examination of Cranial nerves

Olfactory Nerve

No anosmia, parosmia and hallucination of smell.

Optic Nerve

There is no obstruction on the field of vision

Oculomotor Nerve, Trochlear Nerve, Abducens

Ocular movements are within normal limits, no nystagmus. Pupil reacts to light.

Trigeminal Nerve

Sensation over face is intact; corneal and conjunctival reflexes intact.

Jaw jerk present

 

Facial Nerve

Eye closure, frowning, raising the eye brow present

Can blow, whistle and show the teeth
 

Vestibulocochlear Nerve

 

No impairment of hearing

 

Glosopharyngeal Nerves and Vagus

 

Gag reflex present

Uvula centrally placed

 

Hypoglossal Nerve

 

Can move tongue in all directions

 

Sensory System:

 

With in normal limit

 

Examination of motor System:

 

Within normal limits

 

Signs of meningeal irritation:

 

No signs of meningeal irritation

 

Analysis of symptoms

 

Symptoms of disease

Symptoms of patient

Hoarseness of voice

Desires pungent things

Hoarseness of voice< evening

 

Evaluation of symptoms

 

Physical generals

Particulars

Common symptoms

Desires pungent things

Redness of left eye

Hoarseness of voice

 

Totality of Symptoms

1.      Patient desires pungent things

2.      Hoarseness of voice

3.      Hoarseness of voice < Evening

4.      Redness of left eye

5.      Ca larynx

 

Miasmatic cleavage 

 

Symptoms

Psora

Sycosis

Syphilis

Tubercular

Desires pungent    things

 

 

+

 

 

Hoarseness of voice

 

 

+

 

Carcinoma of larynx

 

+

 

+

 

+

 

 

Redness of left eye

 

+

 

 

+

 

+

 

Predominant Miasm: Syphilis

 

Rubrics Selected

  1. STOMACH, DESIRE pungent things.

  2. LARYNX AND TRACHEA VOICE hoarseness.

  3. LARYNX AND TRACHEA VOICE hoarseness evening.

  4. LARYNX AND TRACHEA CANCER larynx.

  5. EYE REDNESS canthi.

 

Medicines

Phosphorous- 9/3               Hepar sulph- 6/3

Carbo veg- 8/3                   Causticum- 6/2

Graphitis- 6/3                     Calcarea carb-

 

Prescription

                       

26-3-05                                               Calcarea Carb 200/2 dose

27-3-05                                   Sac lac 2 dose         

(Hoarseness slightly relieved)

28-4-05                                                                                                 Calc carb 200/2 dose

15-5-05                                                                                               Sac lac 2 dose

(Patient has symptomatic relief and discharged)


 

TUMORS OF THE LARYNX

 

Benign tumours of the larynx are extremely rare and squamous carcinoma of the larynx predominates over all others, being responsible for more than 90% of tumours within the larynx. It is the commonest head and neck cancer and almost always occurs in the elderly male smokers. The squamous epithelium of the vocal folds and the respiratory epithelium of the supraglottis undergo dysplastic change stimulated by cigarette smoking and other factors. The incidence of laryngeal cancer in three compartments- supraglottis, glottis and subglottis, varies around the world; the glottis is generally the commonest site followed by the supraglottis. True carcinomas of the subglottis are very rare and most are a consequence of inferior spread from the glottis.

 

Clinical Features  

            The frequent glottic origin means that patients almost always present with hoarseness. This is of great importance because if a diagnosis can be made while the tumour is in the first stage. I.e. confined to only one vocal fold, these cancers have more than a 5 year disease-free cure rate when treated with radiotherapy alone. The cure rate drops dramatically once the lymphatically rich supraglottis or subglottis is involved, owing to spread to neck nodes. The appearance of more than one neck gland halves the overall prognosis of the patient.

 

TNM Classification of Laryngeal Cancer 

T          -           Primary Tumour

T x       -           Primary tumour cannot be assessed.

To        -           No evidence of primary tumour

T is      -           Carcinoma in site

Supraglottis 

T1 - Tumour limited to one sub site of supraglottis, with normal vocal cord mobility.

T2 - Tumour invades more than one sub site of supraglottis, with normal vocal cord mobility

T3 - Tumour limited to larynx with vocal cord fixation and/ or invades post cricoid area, medial wall of piriform sincit or pre-epiglottic tissues.

T4 - Tumour invades through thyroid cartilage and/ or extends to other tissues beyond the larynx, e.g. to oropharynx, soft tissues of neck.

Glottis 

T1 - Tumour limited to vocal cords, (may involve anterior or posterior commissures) with normal mobility

T1a- Tumour limited to one vocal cord

T1b- Tumour involves both vocal cords

T2 - Tumour extends to supraglottis and/ or with impaired vocal cord mobility

T3 - Tumour limited to larynx with vocal cord fixation.

T4 - Tumour invades through thyroid cartilage and/ or extends to other tissues beyond the larynx; e.g. to oropharynx, soft tissues of the neck.

 

Subglottis

 

T1 - Tumour limited to subglottis

T2 - Tumour extends to vocal cord(s) with normal or impaired mobility.

T3 - Tumour limited to the larynx with vocal cord fixation

T4 - Tumour invades through cricoid or thyroid cartilage and/ or extends to other tissues beyond the larynx; e.g. to oropharynx, soft tissues of the neck.

N   - Regional lymph nodes

M   - Distant metastasis

 

Stage Grouping 

 

Stage 0                        T is                  No                   Mo

Stage I             T1                    No                   Mo

Stage II           T2                    No                   Mo-

Stage III          T1                    N1                   Mo

                        T2                    N1                   Mo

                        T3                    No, N1                        Mo

Stage IV          T4                    No, N1                        Mo

                        Any T              No, N1                        Mo

                        Any T              Any N             M1

 

Investigations

Direct laryngoscopy, together with Hopkins rod examination allows precise determination of the extent tumours and biopsy confirms an exact histology. CT and MRI scanning give further details of the extent of larger tumours and suspicious nodal involvement within the neck which may not be determined on clinical examination.

 

Treatment

Early supraglottis and glottis tumours are optimally treated with mega voltage radiotherapy. Five-year cure for Stages I & II are approximately 90 and 70% respectively, and the patient has an excellent voice following this type of treatment. If modern mega voltage radiotherapy is not available then early tumours may be excised by endoscopic laser surgery or open partial laryngeal surgery. With early bilateral supraglottic tumours a horizontal laryngectomy may be undertaken excising the supraglottic growth and the remainder of the glottis. The subglottic part of the larynx is then stitched tongue base to provide continuity. In most patients undergoing partial laryngeal surgery of this type the voice result is not satisfactory as that with radiotherapy.

 

Advanced Laryngeal Disease 

Once the squamous carcinoma has caused fixation of the vocal fold or has infiltrated outside the larynx into adjacent such as thyroid gland and strap muscles, some form of subtotal or total laryngectomy is required to attempt to cure the disease. Total laryngectomy is frequently required when radiotherapy fails.  Part or all of thyroid gland and associated parathyroid glands may also need to be removed depending on the extent of the disease, so patients after this type of radical surgery may require oral thyroxin and calcium supplement for the remainder of their lives. Laryngectomy patients must obviously avoid immersion in water as this would flow directly into their tracheal stoma.

 

Homoeopathic Management

 

1.      Homoeopathic Medical Repertory by Robin Murphy

 

 

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